Milen Minkov Selected Research

Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell)

1/2022	Vemurafenib acts as a molecular on-off switch governing systemic inflammation in Langerhans cell histiocytosis.
11/2019	Vemurafenib for Refractory Multisystem Langerhans Cell Histiocytosis in Children: An International Observational Study.
6/2018	Langerhans cell histiocytosis in children: History, classification, pathobiology, clinical manifestations, and prognosis.
1/2018	An update on the treatment of pediatric-onset Langerhans cell histiocytosis through pharmacotherapy.
1/2016	Insights into the pathogenesis of Langerhans cell histiocytosis: the development of targeted therapies.
6/2013	Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis.
4/2012	Long-term outcome of hypothalamic pituitary tumors in Langerhans cell histiocytosis.
1/2012	Variant alleles of cytokine genes influence risk and clinical course of Langerhans cell histiocytosis.
3/2008	Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification.
4/2003	Immunosuppressive treatment for chemotherapy-resistant multisystem Langerhans cell histiocytosis.

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Milen Minkov Research Topics

Disease

11	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell) 01/2022 - 12/2002
6	Neoplasms (Cancer) 06/2018 - 03/2006
2	Inflammation (Inflammations) 01/2022 - 09/2017
2	Diabetes Insipidus 01/2021 - 04/2012
2	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 11/2020 - 09/2003
2	Hemolytic Anemia 01/2020 - 05/2016
2	Infections 09/2017 - 03/2009
2	Sickle Cell Anemia (Hemoglobin S Disease) 05/2014 - 04/2013
2	Disease Progression 01/2012 - 07/2004
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 04/2010 - 10/2006
1	COVID-19 related pediatric multisystem inflammatory disease 01/2022
1	Myocarditis (Carditis) 01/2022
1	Hypotension (Low Blood Pressure) 01/2022
1	Exophthalmos (Proptosis) 01/2021
1	beta-Thalassemia (Cooley's Anemia) 05/2014
1	Hypoxia (Hypoxemia) 01/2014
1	primary familial and congenital Polycythemia 01/2014
1	Splenomegaly 12/2013
1	Cytopenia 12/2013
1	Autoimmune Lymphoproliferative Syndrome 12/2013
1	Lymphadenopathy 12/2013
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 08/2013
1	Iron-Refractory Iron Deficiency Anemia 05/2010
1	Body Weight (Weight, Body) 04/2010
1	Neutropenia 03/2009
1	Autosomal Recessive 3 Severe Congenital Neutropenia 01/2009
1	Budd-Chiari Syndrome (Budd Chiari Syndrome) 08/2008
1	Lymphoma (Lymphomas) 08/2008
1	Paraproteinemias (Monoclonal Gammopathy) 03/2007
1	Plasmacytoma 03/2007
1	Sepsis (Septicemia) 10/2006
1	Pathologic Complete Response 12/2005
1	Central Nervous System Diseases (CNS Diseases) 07/2004
1	Pneumonia (Pneumonitis) 09/2003
1	Adenoviridae Infections (Adenovirus Infections) 09/2003
1	Macrophage Activation Syndrome 09/2003

Drug/Important Bio-Agent (IBA)

2	VemurafenibIBA 01/2022 - 11/2019
2	Hemoglobins (Hemoglobin)IBA 01/2020 - 01/2014
2	Inosine Triphosphate (ITP)IBA 04/2010 - 10/2006
1	TroponinIBA 01/2022
1	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022
1	Growth Hormone (Somatotropin)IBA 01/2021
1	Mitogen-Activated Protein KinasesIBA 06/2018
1	AntigensIBA 09/2017
1	Pyruvate KinaseIBA 05/2016
1	2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)IBA 01/2014
1	Oxygen (Dioxygen)IBA 01/2014
1	Erythropoietin FDA Link 01/2014
1	Biomarkers (Surrogate Marker)IBA 12/2013
1	Antihypertensive Agents (Antihypertensives)IBA 08/2013
1	GlucocorticoidsIBA 08/2013
1	Hormones (Hormone)IBA 04/2012
1	CytokinesIBA 01/2012
1	matriptase 2IBA 05/2010
1	HepcidinsIBA 05/2010
1	GlobulinsIBA 04/2010
1	RHO(D) antibody (anti-D)IBA 04/2010
1	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 01/2009
1	Prednisone (Sone)FDA LinkGeneric 12/2005
1	Clarithromycin (Biaxin)FDA LinkGeneric 09/2003
1	Anti-Bacterial Agents (Antibiotics)IBA 09/2003
1	MacrolidesIBA 09/2003
1	Intravenous Immunoglobulins (IVIG)FDA Link 09/2003
1	Indicators and Reagents (Reagents)IBA 12/2002

Therapy/Procedure

9	Therapeutics 01/2018 - 12/2002
6	Drug Therapy (Chemotherapy) 01/2018 - 04/2003
4	Hematopoietic Stem Cell Transplantation 11/2020 - 03/2009
2	Stem Cell Transplantation 11/2020 - 04/2013
1	Critical Care (Surgical Intensive Care) 01/2022
1	Off-Label Use 11/2019
1	General Anesthesia 08/2013
1	Liver Transplantation 08/2008
1	Aftercare (After-Treatment) 08/2008
1	Adenoidectomy 03/2007
1	Splenectomy 10/2006